Prekallikrein Deficiency


Prekallikrein is an enzyme necessary for the activation of certain clotting proteins. Fortunately, this is a benign blood disorder and is not associated with increased bleeding tendencies.

  • Signs and symptoms

    Affected dogs have abnormally long clotting times on laboratory coagulation tests, but this does not lead to an increased bleeding risk clinically.

    Dogs are born with this disorder, but it is often not recognized unless your veterinarian performs certain blood tests.

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  • Diagnosis

    Genetic testing and laboratory clotting times are used to diagnose this condition.

  • Treatment

    At this time, no treatment is required for dogs with this genetic mutation.

  • What to do if your dog is at risk


    • Genetic testing for this benign disorder saves you (and your dog) the time and money that these diagnostics would require.

  • Genetic Information

    This mutation was first identified in a Shih Tzu.

    Dogs must have two copies of the mutation for their prekallikrein levels to be affected.

    Gene names:

    KLKB1 Exon 8 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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