Primary Ciliary Dyskinesia, PCD
PCD arises from a mutation that inhibits the function of motile cellular appendages such as sperm flagella and the cilia of respiratory tract cells. These appendages whip with directionality, allowing sperm to propel themselves towards an egg, and for respiratory tract cells to whip dust, bacteria, and mucus up towards the throat to be coughed out.
-
Signs and symptoms
This disease can cause increased susceptibility to respiratory infections and, in male dogs, reduced fertility or infertility.
Respiratory infections can develop at anytime, however, male fertility can only be assessed after puberty. -
Diagnosis
Genetic and laboratory testing are used to diagnose this condition.
-
Treatment
There is no cure for PCD. Respiratory infections need to be treated promptly with the correct antibiotic.
-
What to do if your dog is at risk
Actions
- Carefully monitor your dog for signs of infection, including: coughing, nasal discharge, and increased respiratory effort.
-
Genetic Information
This mutation was first described in the Alaskan Malamute.
This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.
Gene names:
NME5 ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
