Canine Multiple System Degeneration
A progressive neurologic disease, SERAC1 is necessary for mitochondrial function. Mitochondria are cellular structures that supply the cell with energy (ATP) and have also been linked to cerebellar disease in humans.
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Signs and symptoms
Affected dogs can begin showing gait abnormalities and head tremors. This progresses to difficulty walking towards the end stages of the disease. However, they show no behavioral abnormalities and appear to be aware of their surroundings and companions.
Signs are first apparent around 3 months of age. -
Diagnosis
Unless a genetic basis is suspected due to the age, breed, or history of the dog, diagnostics must be performed to rule out infectious, inflammatory, or neoplastic causes.
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Treatment
There is no treatment for this disorder. Certain medications may be prescribed to control symptoms.
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What to do if your dog is at risk
Actions
- Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.
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Genetic Information
This mutation was first described in the Chinese Crested.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
SERAC1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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