Pyruvate Dehydrogenase Deficiency
This is a disease of glycolysis, the breakdown of glucose for energy.
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Signs and symptoms
Affected dogs have extreme exercise intolerance.
Signs are often first apparent in juveniles. -
Diagnosis
Genetic testing and clinical signs can be used to diagnose this condition.
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Treatment
Dietary changes are typically recommended and involve a high fat, high protein diet. These energy sources don't require pyruvate dehydrogenase for processing. Please speak to your veterinarian before changing your dog's diet.
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What to do if your dog is at risk
Actions
- Please follow your veterinarian's nutritional advice.
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Genetic Information
This mutation was first characterized in the Sussex and Clumber Spaniels.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
PDP1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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