Pyruvate Dehydrogenase Deficiency
This is a disease of glycolysis, the breakdown of glucose for energy.
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Signs and symptoms
Affected dogs have extreme exercise intolerance.
Signs are often first apparent in juveniles.Uncover health risks with Embark
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Diagnosis
Genetic testing and clinical signs can be used to diagnose this condition.
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Treatment
Dietary changes are typically recommended and involve a high fat, high protein diet. These energy sources don't require pyruvate dehydrogenase for processing. Please speak to your veterinarian before changing your dog's diet.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s pyruvate dehydrogenase deficiency result so you can plan appropriate monitoring and care.
- Follow your vet’s nutritional recommendations carefully, as dietary adjustments can help support energy metabolism.
- Watch for signs such as fatigue, weakness, or reluctance to exercise, and contact your vet if you notice any of these.
- Provide a calm, predictable routine to help your dog conserve energy and stay comfortable.
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Genetic Information
This mutation was first characterized in the Sussex and Clumber Spaniels.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
PDP1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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