Metabolic

This is a Metabolic condition.

Pyruvate Dehydrogenase Deficiency

What is Pyruvate Dehydrogenase Deficiency?

A disease characterized by extreme exercise intolerance, this was first characterized in the Sussex and Clumber Spaniels and can be improved to some degree with dietary changes. Affected puppies are usually noticed because they can't keep up with their normal littermates, requiring more rest and naps than your average pup. Dietary changes usually involve a high fat, high protein diet--these energy sources don't require pyruvate dehydrogenase for processing.

What are the signs & symptoms that develop in affected dogs?

Affected dogs have extreme exercise intolerance.

When do signs and symptoms develop?

Signs are often first apparent in juveniles.

How do vets diagnose this condition?

Genetic testing and clinical signs can be used to diagnose this condition.

How is this condition treated?

Dietary changes are typically recommended and involve a high fat, high protein diet. These energy sources don't require pyruvate dehydrogenase for processing. Please speak to your veterinarian before changing your dog's diet.

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