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This is a Metabolic condition.

Pyruvate Dehydrogenase Deficiency

What is Pyruvate Dehydrogenase Deficiency?

This is a disease of glycolysis, the breakdown of glucose for energy.

What are the signs & symptoms that develop in affected dogs?

Affected dogs have extreme exercise intolerance.

When do signs and symptoms develop?

Signs are often first apparent in juveniles.

How do vets diagnose this condition?

Genetic testing and clinical signs can be used to diagnose this condition.

How is this condition treated?

Dietary changes are typically recommended and involve a high fat, high protein diet. These energy sources don't require pyruvate dehydrogenase for processing. Please speak to your veterinarian before changing your dog's diet.

What actions should I take if my dog is affected?

  • Please follow your veterinarian's nutritional advice.