Pyruvate Dehydrogenase Deficiency


This is a disease of glycolysis, the breakdown of glucose for energy.

  • Signs and symptoms

    Affected dogs have extreme exercise intolerance.

    Signs are often first apparent in juveniles.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    Dietary changes are typically recommended and involve a high fat, high protein diet. These energy sources don't require pyruvate dehydrogenase for processing. Please speak to your veterinarian before changing your dog's diet.

  • What to do if your dog is at risk


    • Please follow your veterinarian's nutritional advice.

  • Genetic Information

    This mutation was first characterized in the Sussex and Clumber Spaniels.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    PDP1 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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