Raine Syndrome

Skeletal

While Raine Syndrome causes a number of craniofacial abnormalities in human patients, in dogs, the most predominant sign of the condition is significant tooth wear, which leads to irritation of the dental pulp and considerable tooth pain.

  • Signs and symptoms

    Worn teeth that may have cracks, display discolored enamel, or exposed pulp can be seen in affected dogs.

    Signs are often first recognized in adults.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    Routine dental treatments including tooth extraction is used to manage this disease.

  • What to do if your dog is at risk

    Actions

    • Talk to your vet about your dog’s Raine syndrome result so you can plan appropriate dental care, including regular professional cleanings and exams to monitor for signs of tooth wear or damage.
    • Brush your dog’s teeth regularly using a soft-bristled brush and dog-safe toothpaste to reduce plaque and protect weakened enamel.
    • Avoid hard toys, bones, or treats that could chip or crack fragile teeth.

  • Genetic Information

    This mutation was first described in the Border Collie.

    This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

    Gene names:

    FAM20C ‐ chr

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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