Trapped Neutrophil Syndrome, TNS


Neutrophils, a type of white blood cell that fights infections, are generated in the bone marrow. After an appropriate time to mature, they leave the bone marrow and enter the circulation. The neutrophils of dogs with TNS never fully mature, but remained "trapped" in various stages of immaturity in the bone marrow.

  • Signs and symptoms

    The severity of TNS can vary, but infections can affect any of the body systems: musculoskeletal, respiratory, skin, gastrointestinal, and so forth. Fevers are common. They also have characteristic facial abnormalities including a narrow, elongated skull (described as "ferret-like") and are often smaller than unaffected littermates.

    Some puppies are brought to the vet within weeks for recurrent infections and failure to thrive, others are only diagnosed after reactions to the first set of vaccinations (6-8 weeks), and others go undiagnosed for years after treatment for mild recurrent infections.

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  • Diagnosis

    Genetic and laboratory testing along with clinical signs are used to diagnose this disease.

  • Treatment

    Treatment is symptomatic and based on the body system that has the infection. There is no cure for the underlying cause of this disease.

  • What to do if your dog is at risk


    • Minimizing the risk of infection is the best way to keep your affected dog healthy for as long as possible.

  • Genetic Information

    This mutation was first described in the Border Collie.

    This syndrome is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.

    Gene names:

    VPS13B Exon 19 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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