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Hematologic

This is a Blood condition.

Canine Leukocyte Adhesion Deficiency Type I, CLAD I

What is CLAD I?

CLAD I is a rare disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies. This mutation causes the normal activation of white blood cells and platelets in response to an injury or infection to fail.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have recurrent, severe skin infections (pyoderma), limping (lameness), and/or swollen, bleeding gums (gingivitis). They may also have prominent lymph nodes that are easily felt under the jaw, on the chest, and on the hind legs.

When do signs and symptoms develop?

This disease is typically diagnosed in puppies when they fail to grow, have umbilical infections, and/or swollen lymph nodes. They will also experience chronic infections and/or bleeding following a spay or neuter.

How do vets diagnose this condition?

Genetic or laboratory tests are performed to diagnose this condition.

How is this condition treated?

Currently, treatment for CLAD I focuses on symptomatic management. Judicious, chronic antibiotic use is typically required. Blood products will need to be given following a trauma or surgery.

What actions should I take if my dog is affected?

  • Prevention is ideal, but affected dogs often have a shortened life span despite their owners’ best efforts. Be aware of the location of the nearest emergency veterinary hospital.
  • Regular bathing with antiseptic shampoos, routine dental care, minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a poor outcome.
  • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.