Canine Leukocyte Adhesion Deficiency Type I, CLAD I


CLAD I is a rare disorder of white blood cells that causes increased susceptibility to infections. This mutation causes the normal activation of white blood cells in response to an injury or infection to fail.

  • Signs and symptoms

    Affected dogs may have recurrent, severe skin infections (pyoderma), limping (lameness), and/or swollen, bleeding gums (gingivitis). They may also have prominent lymph nodes that are easily felt under the jaw, on the chest, and on the hind legs.

    This disease is typically diagnosed in puppies when they fail to grow, have umbilical infections, and/or swollen lymph nodes. They may also experience chronic infections following a spay or neuter.

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  • Diagnosis

    Genetic or laboratory tests are performed to diagnose this condition.

  • Treatment

    Currently, treatment for CLAD I focuses on symptomatic management. Judicious, chronic antibiotic use is typically required.

  • What to do if your dog is at risk


    • Prevention is ideal, but affected dogs often have a shortened life span despite their owners’ best efforts. Be aware of the location of the nearest emergency veterinary hospital.
    • Regular bathing with antiseptic shampoos, routine dental care, minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a poor outcome.
    • Be aware of the location of the nearest emergency veterinary hospital.

  • Genetic Information

    This variant was first identified in Irish Setters.

    CLAD I is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    ITGB2 Exon 3 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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