Demyelinating Polyneuropathy

Neuromuscular

Demyelinating polyneuropathy is a disorder that causes a change in neurological function. Dramatic decreases in nerve conduction velocities are observed in affected dogs leading to multiple clinical signs.

  • Signs and symptoms

    Affected dogs often have megaesophagus leading to regurgitation and a quiet or silent bark. Other signs that are inconsistent between affected dogs include delayed reflexes in the limbs, muscle tremors, delayed ocular reflexes, exercise intolerance, and seizures.

    Signs first develop between 3-18 months of age.

    Uncover health risks with Embark

    Embark Breed + Health Test

    Original price:

    $199

    Sale price:

     $159

    Shop

    Embark for Breeders Dog DNA Test

    $129 - $159

    Shop

  • Diagnosis

    Genetic testing, blood work, radiographs, neurological tests, and clinical signs can be used to diagnose this condition.

  • Treatment

    There is no treatment for this condition, however the disease typically remains stable over the long term. Employing feeding measures commonly used for megaesophagus and treating signs of aspiration pneumonia lead to a better prognosis.

  • What to do if your dog is at risk

    Actions

    • Please consult with your veterinarian to determine the best course of management.
    • Special chairs have been developed for feeding dogs with megaesophagus to minimize the risk of aspiration pneumonia.

  • Genetic Information

    This mutation was first described in the Miniature Schnauzer.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    SBF2/MTRM13 ‐ chr21

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

Learn about your dog’s unique genetic health

Dog owners

Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.

Learn about the report for dog owners
Shop the test
Breeding programs

Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.

Learn about the report for breeders
Shop the test