Dystrophic Epidermolysis Bullosa

skin & connective tissue

This skin condition affects a collagen that helps hold skin layers together. When this support is weakened, the skin becomes unusually fragile and stretchy, making it prone to tearing or separating from underlying tissue.

  • Signs and symptoms

    Affected dogs have skin that is injured easily and stretches more than normal.

    Signs first appear in puppies.

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  • Diagnosis

    Genetic testing, skin biopsy, and clinical signs can be used to diagnose this condition.

  • Treatment

    A variety of therapies, including skin grafts, stem cell therapy, and gene therapy, are under investigation for the treatment and prevention of EB, but these are young in development.

  • What to do if your dog is at risk

    Actions

    • Talk to your vet about your dog’s dystrophic epidermolysis bullosa result so you can plan appropriate care and monitoring.
    • Handle your dog gently and use soft bedding materials such as fleece blankets or foam padding to reduce friction and protect the skin.
    • Keep your dog’s environment safe by covering hard floors with rugs or mats and removing sharp edges or rough surfaces that could cause injury.
    • If wounds occur, seek veterinary attention right away to reduce the risk of infection and promote healing.

  • Genetic Information

    This mutation was first described in Golden Retrievers.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    COL7A1 (Exon 68) ‐ chr

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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