Dystrophic Epidermolysis Bullosa
This condition arises from a mutation in Collagen Type VII. Collagens of all types anchor the layers of our skin together: they are what gives skin its springy, youthful texture (and thus are a big component of anti-wrinkle creams). Collagen Type VII has the specific job of connecting the epidermis, the surface layer of the skin, to the underlying tissues, leading to dogs with especially stretchy skin that is easily detached from the underlying tissues.
-
Signs and symptoms
Affected dogs have skin that is injured easily and stretches more than normal.
Signs first appear in puppies. -
Diagnosis
Genetic testing, skin biopsy, and clinical signs can be used to diagnose this condition.
-
Treatment
A variety of therapies, including skin grafts, stem cell therapy, and gene therapy, are under investigation for the treatment and prevention of EB, but these are young in development.
-
What to do if your dog is at risk
Actions
- Trying to prevent injuries from occurring is ideal. Seek treatment immediately if your affected dog is wounded.
-
Genetic Information
This mutation was first described in Golden Retrievers.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
COL7A1 (Exon 68) ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
