Factor VII Deficiency
Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as Factors VIII or IX). Some dogs with this condition will show no clinical signs.
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Signs and symptoms
Affected dogs bruise easily and can excessively bleed from small wounds. Affected puppies may bleed excessively from their mouth when teething. A subset of dogs that test positive for Factor VII deficiency appear perfectly normal.
This disease is typically diagnosed in puppies or young adults when they are spayed or neutered and have a problem with clotting. However, it can be diagnosed at any age. -
Diagnosis
Factor VII deficiency is diagnosed through genetic testing and blood testing at a laboratory. Veterinarians may also nick a dog’s lip with a sterile needle and time how long it takes for clotting to occur.
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Treatment
Factor VII deficiency cannot be treated, only managed.
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What to do if your dog is at risk
Actions
- Please discuss this result with your vet ahead of any potential surgeries.
- Remember that a subset of dogs with this disease appear clinically normal and have no associated problems from this genetic mutation.
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Genetic Information
Factor VII deficiency is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
F7 Exon 5 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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