Glanzmann's Thrombasthenia Type I
A disease of defective platelet aggregation, this causes affected dogs to bleed excessively in response to mild tissue trauma. Normally, platelets clump ("aggregate") together and form a plug at the site of injury. Dogs affected with Glanzmann’s thrombasthenia are unable to aggregate their platelets.
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Signs and symptoms
Affected dogs will bleed excessively when teething or from the nail quick if they are accidentally nicked during nail trimming. They will also bruise easily following even mild trauma. Spontaneous bleeding from the nose (epistaxis) or gums can also be observed.
Signs develop during puppyhood and continue for the rest of the affected dog’s life.Uncover health risks with Embark
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Diagnosis
Genetic and laboratory testing are used to diagnose this condition.
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Treatment
There is no known treatment for this condition. Affected dogs may require blood products following trauma or surgery.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s genetic result, as it could impact upcoming surgeries or procedures.
- Be cautious with activities that could lead to injury, like rough play at dog parks or off-leash hikes.
- To help stop minor bleeding, such as from a broken nail, keep basic first-aid supplies on hand, including bandaging material and styptic powder.
- If your dog is injured, apply gentle pressure with gauze or a clean cloth to the wound. Keep your vet’s contact information handy in case the bleeding doesn’t stop within a few minutes.
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Genetic Information
This disorder was first identified in the Otterhound.
This syndrome is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.
Gene names:
ITGA2B Exon 12 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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