Inherited Myopathy of Great Danes


IMGD stems from a mutation in the BIN1 gene, which produces a protein that controls cell membrane remodeling. This is especially important for muscle development and growth. Loss of BIN1 prevents muscle cells from differentiating correctly, ultimately leading to muscle malfunction and damage in the growing dog.

  • Signs and symptoms

    Signs include weakness, unsteady gait, generalized muscle wasting, and exercise intolerance. The severity of the disease can vary between individuals of the same litter, with some animals being so severely affected that euthanasia is elected and others maintain a good quality of life after symptoms have stabilized.

    Signs develop in juvenile dogs.

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  • Diagnosis

    Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.

  • Treatment

    Currently there is no treatment for IMGD; mildly to moderately affected dogs usually stabilize by 2 years of age and enjoy a normal lifespan.

  • What to do if your dog is at risk


    • Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.

  • Genetic Information

    This mutation was first described in Great Danes.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    BIN1 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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