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Muscular

This is a Muscular condition.

Inherited Myopathy of Great Danes

What is Inherited Myopathy of Great Danes?

This muscle wasting disease causes young dogs to present with weakness, unsteady gait, generalized muscle wasting, and exercise intolerance. The severity of the disease can vary between individuals of the same litter, with some animals being so severely affected that euthanasia is elected and others maintain a good quality of life after symptoms have stabilized. IMGD stems from a mutation in the BIN1 gene, which produces a protein that controls cell membrane remodeling. This is especially important for muscle development and growth. Loss of BIN1 prevents muscle cells from differentiating correctly, ultimately leading to muscle malfunction and damage in the growing dog. Currently there is no treatment for IMGD; mildly to moderately affected dogs usually stabilize by 2 years of age and enjoy a normal lifespan.

What are the signs & symptoms that develop in affected dogs?

Signs include weakness, unsteady gait, generalized muscle wasting, and exercise intolerance. The severity of the disease can vary between individuals of the same litter, with some animals being so severely affected that euthanasia is elected and others maintain a good quality of life after symptoms have stabilized.

When do signs and symptoms develop?

Signs develop in juvenile dogs.

How do vets diagnose this condition?

Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.

How is this condition treated?

Currently there is no treatment for IMGD; mildly to moderately affected dogs usually stabilize by 2 years of age and enjoy a normal lifespan.

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