This is a Gastrointestinal condition.

Inherited Selected Cobalamin Malabsorption with Proteinuria

What is Inherited Selected Cobalamin Malabsorption with Proteinuria?

This is a gastrointestinal disease where dogs cannot absorb cobalamin, often causing them to be small with poor energy levels. Cobalamin is required for synthesis of certain amino acids and is an important factor for a number of other metabolic processes. Dogs cannot generate their own cobalamin but must consume it in their diet. However, dogs with IGS cannot absorb cobalamin from their meals.

What are the signs & symptoms that develop in affected dogs?

Affected puppies are usually runty and have poor energy levels. If not caught at this time, signs can progress to vomiting and seizures.

When do signs and symptoms develop?

Signs first appear in puppies.

How do vets diagnose this condition?

Laboratory testing will show a low red blood cell count. On physical exam, an abnormally slow heart rate will be noted. Genetic testing, clinical signs and additional blood tests are used to diagnose this disorder.

How is this condition treated?

Fortunately, IGS is treatable with regular injections of cobalamin. Early treatment is associated with the best outcome.

What actions should I take if my dog is affected?

  • Please consult your veterinarian regularly for best treatment outcomes.
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