Inherited Selected Cobalamin Malabsorption with Proteinuria
This is a gastrointestinal disease where dogs cannot absorb cobalamin, often causing them to be small with poor energy levels. Cobalamin is required for synthesis of certain amino acids and is an important factor for a number of other metabolic processes. Dogs cannot generate their own cobalamin but must consume it in their diet. However, dogs with IGS cannot absorb cobalamin from their meals.
Signs and symptoms
Affected puppies are usually runty and have poor energy levels. If not caught at this time, signs can progress to vomiting and seizures.
Signs first appear in puppies.
Laboratory testing will show a low red blood cell count. On physical exam, an abnormally slow heart rate will be noted. Genetic testing, clinical signs and additional blood tests are used to diagnose this disorder.
Fortunately, IGS is treatable with regular injections of cobalamin. Early treatment is associated with the best outcome.
What to do if your dog is at risk
- Please consult your veterinarian regularly for best treatment outcomes.
This mutation was first described in Komondors.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
CUBN ‐ chr2
This health condition affects the following breeds
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