Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA
A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. Mucopolysaccharidoses (MPS) are defined by abnormal buildup of glycosaminoglycans, large sugar-protein molecules that are important for skeletal and joint function.
Signs and symptoms
Affected dogs are ataxic, have abnormal eye movements, and head tremors.
Signs typically develop by 3 years of age, and most dogs do not survive more than 2 or 3 years after diagnosis.
Genetic and laboratory testing used to diagnose this disease.
There is no treatment except supportive care for the clinical signs the affected dog develops.
What to do if your dog is at risk
- Focus on palliative therapies to increase your dog's comfort and quality of life.
This mutation was first described in the Dachshund.
This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.
SGSH ‐ chr9
This health condition affects the following breeds
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