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Multisystem

This is a Multisystem condition.

Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA

What is MPS IIIA?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. Mucopolysaccharidoses (MPS) are defined by abnormal buildup of glycosaminoglycans, large sugar-protein molecules that are important for skeletal and joint function.

What are the signs & symptoms that develop in affected dogs?

Affected dogs are ataxic, have abnormal eye movements, and head tremors.

When do signs and symptoms develop?

Signs typically develop by 3 years of age, and most dogs do not survive more than 2 or 3 years after diagnosis.

How do vets diagnose this condition?

Genetic and laboratory testing used to diagnose this disease.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.

What actions should I take if my dog is affected?

  • Focus on palliative therapies to increase your dog's comfort and quality of life.