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Neurologic

This is a Brain and Spinal Cord condition.

Neonatal Encephalopathy with Seizures, NEWS

What is NEWS?

ATF2 is a DNA-binding protein known to mediate the cellular response to DNA damage. It has been linked to a variety of diseases including NEWS; notably, mice deficient in ATF2 have neurologic deficits similar to NEWS puppies.

What are the signs & symptoms that develop in affected dogs?

Affected puppies are often underweight from birth and require intensive nursing care. They can develop cerebellar signs (uncoordinated, difficulty with movement) and seizures.

When do signs and symptoms develop?

Signs develop between 4-6 weeks of age.

How do vets diagnose this condition?

Unless a genetic basis is suspected due to the age, breed, or history of the dog, diagnostics must be performed to rule out infectious, inflammatory, or neoplastic causes.

How is this condition treated?

Currently there is no treatment for NEWS. Due to the severity of their neurologic signs, NEWS puppies do not survive to adulthood.

What actions should I take if my dog is affected?

  • You may need to assist your affected puppy with nursing and other supportive care.