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Neurologic

This is a Brain and Spinal Cord condition.

Neonatal Encephalopathy with Seizures, NEWS

What is NEWS?

A neurologic disease of puppies, affected puppies are often smaller than their unaffected littermates and require intensive nursing care. Without this extra support, puppies often do not survive past a few weeks of age. Affected puppies can develop cerebellar signs and seizures by 4 to 6 weeks of age, which requires close monitoring and management. In Poodles, a mutation in the ATF2 gene has been linked to this condition. ATF2 is a DNA-binding protein known to mediate the cellular response to DNA damage. It has been linked to a variety of diseases including NEWS; notably, mice deficient in ATF2 have neurologic deficits similar to NEWS puppies. Currently there is no treatment for NEWS. Due to the severity of their neurologic signs, NEWS puppies do not survive to adulthood.

What are the signs & symptoms that develop in affected dogs?

Affected puppies are often underweight from birth and require intensive nursing care. They can develop cerebellar signs (uncoordinated, difficulty with movement) and seizures.

When do signs and symptoms develop?

Signs develop between 4-6 weeks of age.

How do vets diagnose this condition?

Unless a genetic basis is suspected due to the age, breed, or history of the dog, diagnostics must be performed to rule out infectious, inflammatory, or neoplastic causes.

How is this condition treated?

Currently there is no treatment for NEWS. Due to the severity of their neurologic signs, NEWS puppies do not survive to adulthood.

What actions should I take if my dog is affected?

You may need to assist your affected puppy with nursing and other supportive care.

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