Osteochondrodysplasia
As a fetus, most of the bones of the body actually start as cartilage models of themselves. Over time, the cartilage is replaced with the bones that you (and your dog) are born with. Dogs affected with osteochondrodysplasia have a mutation in the SLC13A1 gene, which codes for a protein that transports minerals into the developing bone. Defects in this gene disrupt the cartilage to bone transition, leading to inappropriate skeletal development.
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Signs and symptoms
Affected dogs have abnormally short legs but a normal sized body. They can also have changes to their rib cage and an underbite.
Signs are first recognized in puppies.Uncover health risks with Embark
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Diagnosis
Genetic testing and clinical signs can be used to diagnose this condition.
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Treatment
There is no treatment for this condition.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s osteochondrodysplasia result so you can discuss whether any signs are present and plan care based on their individual needs.
- Some dogs show only mild limb shortening, while others may have significant mobility or breathing challenges.
- Keep your dog’s environment safe with nonslip mats, soft bedding, and ramps or stairs to help them move around more easily and avoid strain on their joints.
- Arthritis can develop over time, so regular checkups and weight management can help your dog stay as active and comfortable as possible.
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Genetic Information
This mutation was first described in Miniature Poodles.
This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.
Gene names:
SLC13A1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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