Canine Leukocyte Adhesion Deficiency Type III, CLAD III
CLAD III is a rare disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies.This mutation causes the normal activation of white blood cells and platelets in response to an injury or infection to fail.
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Signs and symptoms
Affected dogs may have recurrent, severe skin infections (pyoderma), limping (lameness), and/or swollen, bleeding gums (gingivitis).
This disease is typically diagnosed in puppies or young adults when they experience chronic infections and/or bleeding following a spay or neuter.Uncover health risks with Embark
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Diagnosis
Genetic or laboratory tests are performed to diagnose this condition.
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Treatment
Currently, treatment for CLAD III focuses on symptomatic management. Judicious, chronic antibiotic use is typically required. Blood products will need to be given following a trauma or surgery.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s CLAD result, as it may influence how they monitor your dog’s health and prepare for any surgeries or procedures.
- Practice good hygiene, including regular bathing with a gentle or antiseptic shampoo and routine dental care, to help reduce infection risk.
- Be cautious with activities that could cause injury, like rough play at dog parks or off-leash hikes, and seek prompt veterinary care for any wounds, illnesses, or signs of infection.
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Genetic Information
This variant was first identified in German Shepherds.
CLAD III is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
FERMT3 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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