Canine Leukocyte Adhesion Deficiency Type III, CLAD III

Blood

CLAD III is a rare disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies.This mutation causes the normal activation of white blood cells and platelets in response to an injury or infection to fail.

  • Signs and symptoms

    Affected dogs may have recurrent, severe skin infections (pyoderma), limping (lameness), and/or swollen, bleeding gums (gingivitis).

    This disease is typically diagnosed in puppies or young adults when they experience chronic infections and/or bleeding following a spay or neuter.

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  • Diagnosis

    Genetic or laboratory tests are performed to diagnose this condition.

  • Treatment

    Currently, treatment for CLAD III focuses on symptomatic management. Judicious, chronic antibiotic use is typically required. Blood products will need to be given following a trauma or surgery.

  • What to do if your dog is at risk

    Actions

    • Prevention is ideal, but affected dogs often have a shortened life span despite their owners’ best efforts. Be aware of the location of the nearest emergency veterinary hospital.
    • Regular bathing with antiseptic shampoos, routine dental care, minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a poor outcome.
    • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.

  • Genetic Information

    This variant was first identified in German Shepherds.

    CLAD III is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    FERMT3 ‐ chr18

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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