Canine Multifocal Retinopathy, cmr3


This is a non-progressive retinal disease that, in rare cases, can lead to vision loss. Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

  • Signs and symptoms

    Most dogs affected with CMR show no clinical signs. Mild vision loss may be apparent in the worst cases and include bumping into walls and a reduced ability to track toys or other objects.

    CMR typically develops in puppies at 11 to 16 weeks and becomes stable by the time they are 1 year old.

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  • Diagnosis

    CMR is typically only identified when a vet examines the back of the eye which, in dogs with CMR, reveals multiple retinal abnormalities that range from small, flat folds (called "retinal folds") to larger, irregularly edged raised lesions (called "geographic lesions").

  • Treatment

    Currently, there is no treatment for CMR. However, CMR rarely affects vision to a significant degree, and as we stated, even the associated retinal abnormalities can regress over time.

  • What to do if your dog is at risk


    • Carefully monitoring your dog's vision and seeking a veterinary ophthamologist's opinion if you are concerned are the best ways you can help your affected dog.

  • Genetic Information

    This mutation was first identified in the Lapponian Herder.

    CMR is inherited in an autosomal recessive manner. Dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    BEST1/VMD2 Exon 10 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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