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This is a Multisystem condition.

Pompe's Disease

What is GSD II?

This form of glycogen storage disease can cause progressive weight loss, vomiting, and cardiac abnormalities. Glycogen is the form in which our bodies store sugar: they are long, complex molecules that are primarily stored in the liver, heart, kidney, and muscle and are those tissues’ primary source of energy. In GSDs, glycogen accumulates to abnormal levels leading to enlargement and malfunction of these vital organs. Glycogen storage diseases (GSDs) occur in dogs, humans, and other animals. There are four types of GSDs known in dogs and these match Type I, II, IIIa and VII GSDs in humans. Dogs with Type II GSD are often severely affected by the disease and require close monitoring and supportive care.

What are the signs & symptoms that develop in affected dogs?

This form of glycogen storage disease can cause progressive weight loss, vomiting/regurgitation, and cardiac abnormalities. Breathing difficulties secondary to heart failure and/or megaesophagus are also common.

When do signs and symptoms develop?

Onset of signs is typically around 6 months and rapidly progresses until death around 1.5 years.

How do vets diagnose this condition?

Genetic and laboratory testing used to diagnose this disease. Imaging modalities (radiographs, ultrasound) are used to diagnose secondary complications.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.