Platelet Factor X Receptor Deficiency, Scott Syndrome
Canine Scott Syndrome is a defect in platelet function leading to impaired secondary hemostasis. Secondary hemostasis occurs after a platelet "plug" has formed. Its role is to make the plug stable by adding fibrin to the clot. Dogs with CSS have platelets that cannot signal in response to stimuli to induce platelet activation or death.
-
Signs and symptoms
If your affected dog suffers a major trauma or undergoes surgery, they may not be able to clot well leading to increased blood loss or internal bleeding.
Dogs are born with this condition.Uncover health risks with Embark
Embark Breed + Health Test
- Regular Price
$199
- Sale Price
- $125
Embark for Breeders dog DNA test kits
- Sale Price
- $119-$139 per test
-
Diagnosis
Genetic and laboratory testing can be used to diagnose this disorder.
-
Treatment
There is no cure for this condition. Dogs with this disease may need blood/platelet transfusions during surgery or following a major trauma. However, they should have a normal lifespan.
-
What to do if your dog is at risk
Actions
- Plan major surgeries with your veterinarian in advance and inform them of your dog’s potential for bleeding.
-
Genetic Information
This mutation was first identified in the German Shepherd Dog.
This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.
Gene names:
TMEM16F ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
