Multisystem

This is a Multisystem condition.

Renal Cystadenocarcinoma and Nodular Dermatofibrosis

What is RCND?

A multiorgan syndrome best described in the German Shepherd Dog, affected dogs display thick skin nodules and signs of kidney disease, and should be evaluated by a veterinarian. Affected females also develop tumors of the uterine smooth muscle, known as leiomyomas, which can be removed surgically. Signs of kidney disease arise from spontaneous renal tumors which reduce kidney function and can lead to renal failure. Renal cystadenocarcinomas can also metastasize to the lungs, leading to respiratory distress. Treatment for RCND remains palliative to increase your dog's comfort and quality of life.

What are the signs & symptoms that develop in affected dogs?

Signs of this disease include thick skin nodules, excessive thirst and urination, uterine tumors (leiomyomas) in females, and kidney tumors (renal cystadenocarcinoma). If the cancer metastasizes to the lungs, affected dogs can have respiratory distress.

When do signs and symptoms develop?

First signs usually develop around 5 years of age, with death from the disease likely around 9 years of age.

How do vets diagnose this condition?

Genetic and laboratory testing are used to diagnose this condition. Abdominal ultrasound is used to visualize the uterus.

How is this condition treated?

There is no treatment for RCND. Certain medications, fluid therapy, and surgical management may be recommended.

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