Renal Cystadenocarcinoma and Nodular Dermatofibrosis


Hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a multiorgan syndrome that creates dense collagen nodules in the skin and causes cancer in the kidneys and uterus.

  • Signs and symptoms

    Signs of this disease include thick skin nodules, excessive thirst and urination, uterine tumors (leiomyomas) in females, and kidney tumors (renal cystadenocarcinoma). If the cancer metastasizes to the lungs, affected dogs can have respiratory distress.

    First signs usually develop around 5 years of age, with death from the disease likely around 9 years of age.

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  • Diagnosis

    Genetic and laboratory testing are used to diagnose this condition. Abdominal ultrasound is used to visualize the uterus.

  • Treatment

    There is no treatment for RCND. Certain medications, fluid therapy, and surgical management may be recommended.

  • What to do if your dog is at risk


    • Focus on palliative therapies to increase your dog's comfort and quality of life.

  • Genetic Information

    This mutation was first described in the German Shepherd Dog.

    This mutation is inherited in an autosomal dominant manner, meaning that one or two copies of this gene will cause the disorder. There is strong evidence that two copies of the mutation is lethal in utero.

    Gene names:

    FLCN ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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