Anhidrotic Ectodermal Dysplasia
XHED has been mapped to a mutation in the EDA gene, leading to a defective ectodysplasin protein, which is known to play a role in hair follicle and tooth bud development. This developmental condition can cause a scanty hair coat, malformed teeth, and few or absent sweat glands.
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Signs and symptoms
Affected puppies have symmetrical hair loss and missing or malformed teeth.
Affected dogs are often first noted at birth, although signs continue to develop into adulthood.Uncover health risks with Embark
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Diagnosis
Genetic and laboratory testing are used to diagnosis this disorder.
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Treatment
Because dogs only have sweat glands on their paw pads, they are not prone to overheating--other than dietary changes to accommodate missing teeth and appropriate measures to protect skin from sunburn or over drying, affected dogs can lead healthy and normal lives.
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What to do if your dog is at risk
Actions
- Monitor your affected dog closely for respiratory infections, as these can prove deadly.
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Genetic Information
This mutation was first described in the German Shepherd Dog.
This mutation has a sex-linked recessive inheritance pattern, which means that the gene is on the X chromosome. Females have two X chromosomes and must inherit two abnormal copies to be affected with this disease. Males have only one X chromosome and either have a normal copy of the gene or the mutation. Males with the mutation typically die at 2-15 months of age. Carrier females tend to have excessive protein in their urine, but a normal lifespan.
Gene names:
EDA ‐ chr
Inheritance type:
x-linked recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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