Exercise-Induced Collapse, EIC
EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.
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Signs and symptoms
This muscle disorder can cause episodes of muscle weakness and sometimes collapse. After recovering, most dogs are perfectly normal and eager to get back to work. While most dogs appear dazed or confused after an episode, most return to normal quickly.
Signs develop in juvenile dogs, typically before 3 years of age. -
Diagnosis
Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.
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Treatment
Dogs with this condition are otherwise normal and healthy, though some severely affected dogs have died during an episode. The factors determining the severity of an episode on a given day or in a given dog is unknown.
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What to do if your dog is at risk
Actions
- Minimizing or eliminating intense exercise is the best way we currently know to prevent complications from this condition.
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Genetic Information
This mutation was first characterized in field-trial lines of Labrador Retriever dogs.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs. However, this mutation is incompletely penetrant, meaning that not all dogs with two copies of the mutation will show signs of this disease.
Gene names:
DNM1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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Bouvier des Flandres
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Boykin Spaniel
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Cardigan Welsh Corgi
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Chesapeake Bay Retriever
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Clumber Spaniel
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Cocker Spaniel
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Curly-Coated Retriever
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English Cocker Spaniel
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Field Spaniel
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German Wirehaired Pointer
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Labrador Retriever
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Old English Sheepdog
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Pembroke Welsh Corgi
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Rhodesian Ridgeback
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Vizsla
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Wirehaired Vizsla
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