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This is a Multisystem condition.

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII

What is MPS VII?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. Mucopolysaccharidoses (MPS) are defined by abnormal buildup of glycosaminoglycans, large sugar-protein molecules that are important for skeletal and joint function.

What are the signs & symptoms that develop in affected dogs?

Puppies display severe skeletal abnormalities, have large heads with short muzzles, broad faces, and such crooked legs that they cannot walk.

When do signs and symptoms develop?

Signs are apparent at 4-8 weeks of age and an inability to walk by 5 months of age.

How do vets diagnose this condition?

Clinical signs and genetic testing used to diagnose this disease.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.

What actions should I take if my dog is affected?

  • Focus on palliative therapies to increase your dog's comfort and quality of life.